abstract：:The loci coeruleus of freely moving cats were perfused bilaterally with acetylcholine at a dose of 0.001 microgram/microliter per min, while the animals were recorded polygraphically. The controls consisted of experiments in which no perfusions were done, and experiments in which the loci coeruleus were perfused bilat...

journal_title：Neuropharmacology

authors： Masserano JM,King C

更新日期：1982-11-01 00:00:00

abstract：:The electrophysiological properties and cataleptogenicity of YM-09151-2 (N-[(2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide) were studied in the cat. This drug inhibited the EEG arousal response to electrical stimulation of the mesencephalic reticular formation with the same pote...

journal_title：Neuropharmacology

authors： Yamamoto M,Usuda S,Tachikawa S,Maeno H

更新日期：1982-10-01 00:00:00

abstract：:Groups of hypophysectomised rats were given either an electroconvulsive shock (ECS; 125V, 1 sec) once daily for 10 days or a sham-shock. Twenty-four hours after the final treatment both groups were tested for their responses to the dopamine agonist, apomorphine, the 5-hydroxytryptamine agonist, quipazine, and the alph...

journal_title：Neuropharmacology

authors： Nutt DJ,Smith SL,Heal DJ

更新日期：1982-09-01 00:00:00

abstract：:Histidine injected intraperitoneally into rats in doses from 400 to 800 mg/kg induced a dose-dependent bizarre behaviour. The behaviour after histidine was similar to that observed after L-DOPA and peripheral decarboxylase inhibition. The bizarre behaviour was antagonized by chloropyramine, ketotifen, clemastine and p...

journal_title：Neuropharmacology

authors： Pilc A,Rogóz Z,Skuza G

更新日期：1982-08-01 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature. For the hypothermic effect, i.e. a decrease in temperature by at least 1.5 degree C, ED50's were estimated with these peptides and...

journal_title：Neuropharmacology

authors： Zetler G

更新日期：1982-08-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:Striking circadian changes in behavioral sensitivity to haloperidol were found by measurements of cataleptic responses in rats trained in a controlled lighting cycle (lights on, 7:00 a.m.--7:00 p.m.). Thus, catalepsy was maximal at about 4:00 p.m. and minimal at about 4:00 a.m., virtually the opposite of the circadian...

journal_title：Neuropharmacology

authors： Campbell A,Herschel M,Sommer B,Madsen JR,Cohen BM,Baldessarini RJ

更新日期：1982-07-01 00:00:00

abstract：:The effects of haloperidol, chlorpromazine and clozapine on transmitter release have been studied by measuring the simultaneous release of dopamine and acetylcholine from tissue slices of nucleus accumbens and striatum in vitro following in vivo drug application, either a single dose or daily for periods of up to 25 d...

journal_title：Neuropharmacology

authors： de Belleroche JS,Neal MJ

更新日期：1982-06-01 00:00:00

abstract：:The influence of repeated administration of imipramine on the EEG and behavioural effects of clonidine has been studied in the rat bearing chronic electrodes. Clonidine induced behavioural depression and EEG synchronization in control rats. Mydriasis, hyperirritability, stereotyped behaviour and EEG desynchronization ...

journal_title：Neuropharmacology

authors： Passarelli F,de Carolis AS

更新日期：1982-06-01 00:00:00

abstract：:Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, alt...

journal_title：Neuropharmacology

authors： Yamamoto K,Sawada T,Utsumi S,Naito Y,Koshida H

更新日期：1982-05-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:The effects of chronic administration of the nonselective monoamine oxidase (MAO) inhibitor, phenelzine, and two selective inhibitors, clorgyline, and pargyline on adrenergic receptor binding and MAO activity were studied in the rat brain. Chronic but not acute administration of both phenelzine and the MAO-A inhibitor...

journal_title：Neuropharmacology

authors： Cohen RM,Campbell IC,Dauphin M,Tallman JF,Murphy DL

更新日期：1982-04-01 00:00:00

abstract：:The effects of d- and l-amphetamine were studied on key-pressing responses of squirrel monkeys maintained under fixed-interval schedules of electric shock presentation, and on key-pecking responses of pigeons maintained under multiple fixed-ratio, fixed-interval schedules of food presentation. Under the fixed-interval...

journal_title：Neuropharmacology

authors： Katz JL

更新日期：1982-03-01 00:00:00

abstract：:Radioligand binding assays were used to demonstrate the presence of alpha 1, alpha 2 and beta receptors in rat spinal cord. Specific and saturable binding was exhibited for [3H]-WB 4101 (alpha 1), [3H]-aminoclonidine (alpha 2) and [3H]-dihydroalprenolol (beta). Binding was of high affinity and the total number of bind...

journal_title：Neuropharmacology

authors： Jones DJ,Kendall DE,Enna SJ

更新日期：1982-02-01 00:00:00

abstract：:A once daily injection to rats of triiodothyronine (T3; 100 micrograms/kg s.c.) for 10 days enhanced the locomotor responses of rats pretreated with tranylcypromine (5 mg/kg) to an injection into the nucleus accumbens of dopamine (5 micrograms bilaterally), when tested 24 hr after the last T3 administration. This trea...

journal_title：Neuropharmacology

authors： Heal DJ,Atterwill CK

更新日期：1982-02-01 00:00:00

abstract：:Rats injected intrastriatally with kainic acid (KA), in contrast to sham-treated (control) animals, showed no tolerance toward catalepsy induced by chronic haloperidol treatment (28 days). After termination of chronic haloperidol treatment in control animals, apomorphine-induced stereotypy was significantly enhanced a...

journal_title：Neuropharmacology

authors： Zarkovsky AM,Nurk AM,Rägo LK,Allikmets LH

更新日期：1982-02-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of histamine in chloral anaesthetized rats exposed to an ambient temperature of 22 C elicited a rise in their colonic temperature associated with a shivering. This effect was shared by the H2 receptor agonists dimaprit and impromidine. Impromidine is, in this respect, a ...

journal_title：Neuropharmacology

authors： Colboc O,Protais P,Costentin J

更新日期：1982-01-01 00:00:00